Between the retirement of Jimmie Johnson and Clint Bowyer and a number of driver and car changes; the 20201 NASCAR Cup Series lineup for 2021 will have a lot of changes.

Currently the list of full time drivers set to run the 2021 season are:
Kurt Busch in the number one car driving for Chip Ganassi Racing
Brad Keselowski driving the number two car for Team Penske
Austin Dillon driving the number three car for Richard Childress Racing
Kevin Harvick driving the number four car for Stewart-Haas Racing
Kyle Larson driving the number five car for Hendrick Motorsports – Larson is returning to the Cup Series after a suspension
Ryan Newman driving the number six car for Roush Fenway Racing
Corey LaJoie driving the number seven car for S;ire Motorsports
Tyler Reddick driving the number eight car for Richard Childress Racing
Chase Elliott driving the number nine car for Hendrick Motorsports – Elliott is the reigning Cup Series champion
Aric Almirola driving the number 10 car for Stewart-Haas Racing
Denny Hamlin driving the number eleven car for Joe Gibbs Racing
Ryan Blaney driving the number 12 car for Team Penske
Chase Briscoe driving the number 14 car for Stewart-Haas Racing – Briscoe moves up from the Xfinity Series
Chris Buescher driving the number 17 car for Roush Fenway Racing
Kyle Busch driving the number 18 car for Joe Gibbs Racing
Martin Truex Jr driving the number 19 car for Joe Gibbs Racing
Christopher Bell driving the number 20 car for Joe Gibbs Racing – this is a new team for Bell this season
Matt DiBenedetto driving the number 21 car for Wood Brothers Racing
Joey Logano driving the number 22 car for Team Penske
Bubba Wallace driving the number 23 car for 23XI Racing – this is a new team and a new team for Wallace
William Byron driving the number 24 car for Hendrick Motorsports
Michael McDowell driving the number 34 car for Front Row Motorsports
Ryan Preece driving the number 37 car for JTG Daugherty Racing
Cole Custer driving the number 41 car for Stewart-Haas Racing
Ross Chastain driving the number 42 car for Chip Ganassi Racing
Erik Jones driving the number 43 car for Richard Petty Motorsports – this is a new team for Jones
Ricky Stenhouse Jr driving the number 47 car for JTG Daugherty Racing
Alex Bowman takes over driving the number 48 for Hendrick Motorsports
BJ McLeod driving the number 78 for Live Fast Motorsports
Daniel Suarez driving the number 99 for Trackhouse

NASCAR has spots for 40 cars in each race; with the current list of full time drivers, there is plenty of room for part timers and special occasion drivers.